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Les patients atteints d'insuffisance rénale terminale présentent une augmentation de la C max (1,8×) et de l'ASC (6,5×); la demi-vie moyenne d'élimination de l'aciclovir administré sous forme de valaciclovir est alors d'environ 14 heures, plaquenil and eye damage rapport à 3 heurs chez les personnes sans insuffisance rénale (cf.
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